Biochemical
and Bioimaging Endpoints in Cardiocerebrovascular Diagnosis,
Prevention, Therapy and Drug Development
GLOSSARY
To
facilitate the dialogue among the multidisciplinary scientists,
definition of the acronyms and of more specialized terms have been
reported.
Every amendment is welcome.
By: Andrea P. Peracino
Stefano Bellosta
Nicola Ferri
Riccardo Roggeri
Angiotensin II is the final active messenger of the renin-angiotensin pathway Angiotensin II binds to AT1 receptors to cause vasoconstriction and fluid retention, both of which lead to an increase in blood pressure. The angiotensin II receptor blockers lower blood pressure by blocking the AT1 receptors.
Endothelium in Atherogenesis: the early endothelium damage is prompeted by several factors icluding oxidised LDL, with protective effect of HDL; activated neutrophiles and macrophages adher to the damaged endothelium; activated macrophages become foam cells by uptake of oxidized LDL, and synthetize Angiotensin II to promotes oxidative stress caused by reactive oxygene species (ROS) ant stimulate the formation of VICAM, and promotes growth of Vascular Smooth Cells (VSM)
